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Inventi Impact: Biomedical Analysis

Articles

  • Inventi:pba/33475/20
    Determination of Lekethromycin, a Novel Macrolide Lactone, in Rat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study
    Research 2021 : January - March
    Hongzhi Xiao, Pan Sun, Jicheng Qiu, Jianzhong Wang, Lei Yan, Suxia Zhang, Xingyuan Cao

    Lekethromycin, a new macrolide lactone, exhibits significant antibacterial activity. In this\nstudy, a reliable analytical ultrahigh-performance liquid chromatography electrospray ionization\nquadrupole Orbitrap high-resolution mass spectrometry (UPLC-ESI-Orbitrap-MS) method was\nestablished and validated for the detection of lekethromycin in rat plasma. After a simple acetonitrile\n(ACN)-mediated plasma protein precipitation, chromatographic separation was performed on a\nPhenomenex Luna Omega PS C18 column.........................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Xiao, Hongzhi, et al. \"Determination of Lekethromycin, a Novel Macrolide Lactone, in\nRat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study.\" Molecules 25.20 (2020): 4676.\nhttps://doi:10.3390/molecules25204676\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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